患有慢性病的患者骨硬化的危险因素:一个嵌套病例对照研究
Ken Iseri1,2, Noriko Hida1
1Division of Clinical Research and Development, Department of Clinical Pharmacy, School of Pharmacy, Showa University, Tokyo 142-8666, Japan.
概括
慢性病 (CKD) 患者的骨瘤 (ONJ) 风险与瘤抗复苏药物和口服皮质类固醇有关. 功能在本研究中没有显著影响ONJ风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨 (ONJ) 严重影响患者的生活质量.
- 在慢性病 (CKD) 患者中,ONJ的危险因素尚不清楚.
- 识别这些风险因素对于患者管理和预防策略至关重要.
研究的目的:
- 在一大批慢性病患者中调查与ONJ相关的风险因素.
- 确定在这个人群中增加ONJ风险的特定药物和患者特征.
- 提供基于证据的建议,以管理慢性病患者的ONJ风险.
主要方法:
- 使用日本行政数据库进行了嵌套病例控制研究.
- 通过估计的淋巴细胞过率 (eGFR) 确定了CKD患者.
- 使用ICD-10代码和诊断术语识别了ONJ病例,对照组与年龄和性别相匹配1:4.
主要成果:
- 在597,026名CKD患者中,发现了75例ONJ病例.
- 与瘤相关疾病的抗吸收药物 (OR: 74.74) 和口服皮质类固醇 (OR: 13.23) 与增加的ONJ风险有显著联系.
- 功能和ONJ风险之间没有发现显著的关联;治疗骨质疏松症的双酸盐也没有与风险增加有关.
结论:
- 用于瘤相关疾病的抗吸收药物和口服皮质类固醇是CKD患者ONJ的重要危险因素.
- 建议对接受这些特定药物的CKD患者进行加强监测.
- 早期检测和干预策略对于改善ONJ风险的CKD患者的治疗结果至关重要.
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