Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Remodeling01:40

Bone Remodeling

38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
Bone Disorders01:29

Bone Disorders

3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

An index of net bone formation relative to resorption is associated with incident fracture during the menopause transition and postmenopause.

JBMR plus·2026
Same author

Improving and Sustaining Equity Content and Quality in Graduate Medical Education.

Journal of graduate medical education·2026
Same author

Management of Osteoporosis and Low Bone Mass in Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Efficacy, pharmacodynamics, pharmacokinetics, safety, and immunogenicity of Bmab 1000 vs reference denosumab: 78-wk results from a randomized, double-blind, multicenter, parallel-arm Phase 3 trial (DEVOTE) in women with postmenopausal osteoporosis.

JBMR plus·2026
Same author

Improvement of Bone Mineral Density in Patients with Type 1 Gaucher Disease Treated with Velaglucerase Alfa: Results from Clinical Studies.

Journal of clinical medicine·2026
Same author

Monte Carlo Resampling Validates Use of Bone Mineral Density Change as Surrogate to Replace Fracture in Future Randomized Trials of Osteoporosis Treatments: Results From SABER.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

相关实验视频

Updated: Jun 5, 2025

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
06:31

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

7.3K

使用参考骨周转率标志物估计骨净形成相对于再吸收.

Albert Shieh1, Arun S Karlamangla1, Fatma Gossiel2

  • 1Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles.

The Journal of clinical endocrinology and metabolism
|December 10, 2024
PubMed
概括
此摘要是机器生成的。

一个新的骨平衡指数 (BBI),结合了再吸收 (CTX) 和形成 (PINP) 标记,预测了骨矿物质密度 (BMD) 的损失. 不太有利的BBI表明BMD下降速度更快,这对于了解更年期骨健康至关重要.

关键词:
骨头的周转率 骨头的周转率骨周转率标志物 骨周转率标志物队列队列队列队列队列流行病学流行病学在纵向的长度上.更年期 绝经 绝经

更多相关视频

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.2K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.6K

相关实验视频

Last Updated: Jun 5, 2025

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
06:31

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

7.3K
Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.2K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.6K

科学领域:

  • 骨生物学和新陈代谢
  • 内分泌学和代谢障碍 代谢障碍
  • 老年学和老年医学是老年学和老年医学.

背景情况:

  • 骨重塑涉及再吸收和形成,但个别标记物并不完全代表骨平衡.
  • 评估骨健康需要集成的标记物来理解骨净变化.

研究的目的:

  • 开发一个骨平衡指数 (BBI) 通过结合原蛋白类型I C-telopeptide (CTX) 和原蛋白类型I propeptide (PINP) 标记物.
  • 研究BBI,CTX,PINP与骨矿物质密度 (BMD) 变化之间的关联.

主要方法:

  • 利用一个以社区为基础的队列 (全国各地妇女健康研究) 的535名妇女经历更年期过渡.
  • 采用混合效应线性回归来分析BBI,CTX,PINP之间的关系,以及腰椎 (LS) 和大腿部 (FN) BMD的年化百分比变化.
  • 调整了包括年龄,体重指数,种族/种族和更年期过渡阶段在内的共同变量.

主要成果:

  • 更负的BBI与LS和FN的每年BMD损失显著增加有关.
  • 每个标准偏差下降的BBI与LS BMD下降幅度增加0.26%,FN BMD下降幅度增加0.42%.
  • 单独升高的CTX或PINP水平也预测了骨质损失的增加,CTX与LS BMD下降有更强的关联.

结论:

  • BBI有效地估计了骨平衡,不太有利的BBI预测了加速的BMD损失.
  • 个别标记物CTX和PINP反映了整体骨周转,较高的水平与更大的骨损失有关.
  • 这些发现突显了BBI组合用于评估骨健康和预测骨质量变化的实用性,特别是在更年期妇女中.