在试点优化试验中评估多维忠实性:对四个干预组件的过程评估,以支持乳腺癌妇女的药物坚持
Sophie M C Green1, Christopher D Graham2, Michelle Collinson3
1Leeds Institute of Health Sciences, University of Leeds, Leeds LS2 9NL, UK.
Translational behavioral medicine
|December 10, 2024
概括
乳腺癌患者对辅助内分泌治疗的低坚持性被使用试点试验来解决. 四个干预措施 (短信,传单,ACT,网站) 显示出足够的忠实性,其中ACT颁布报告最为积极.
科学领域:
- 在瘤学瘤学.
- 行为科学 行为科学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 坚持辅助内分泌疗法 (AET) 对乳腺癌治疗结果至关重要,但仍然不理想.
- 现有的干预措施往往缺乏对其实施忠实性的严格评估.
研究的目的:
- 评估四个干预组件 (短信,信息传单,接受和承诺治疗,自我管理网站) 在支持AET坚持方面的忠实性.
- 在多阶段优化战略 (MOP) 准备阶段提供忠实性评估的示例.
主要方法:
- 一个24-1分数因子试点优化试验随机分配52名妇女到四种干预措施的八种组合中.
- 在设计,培训,交付,接收和颁布方面评估了忠诚度,使用多种方法,包括自我报告,观察和采访.
- 美国国立卫生研究院行为改变联盟的忠诚度框架指导了评估.
主要成果:
- 所有干预组件在评估领域都表现出足够的忠实性.
- 在接受和承诺疗法 (ACT) 交付过程中观察到高的程序忠实度 (85.1%-94.3%).
- 参与者收到组件的情况有所不同,ACT和传单的收到率为63.0%,短信的收到率为71.4%.
结论:
- 经过测试的干预组件,一旦实施,可以实现足够的忠实性来支持AET遵守.
- 该研究为评估早期优化研究中的干预忠实性提供了实际框架.
- 进一步的研究应解决技术问题,例如短信传递错误,以最大限度地扩大干预范围.
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