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通过光共振能量转移方法评估酸放射对比剂干扰ADAMTS13活动测试的潜力

Jeremy W Jacobs^1,2, Melissa S Stuart², Julie I Tange²

¹Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, US.

American journal of clinical pathology

|December 10, 2024

概括

像Omnipaque这样的化对比剂不会干扰基于光共振能量转移 (FRET) 的ADAMTS13活性测定. 这意味着ADAMTS13对血栓性血栓塞性紫外线的测试可以在对比剂施用后立即进行.

科学领域:

生物化学生物化学
医学诊断医学诊断医学诊断
血液学血液学血液学

背景情况:

基于光共振能量转移 (FRET) 的测定对于诊断血栓性血栓细胞性紫外线 (TTP) 至关重要.
这些测试可能容易受到各种物质的干扰,包括含化合物.
离子对比介质通常用于医学成像.

研究的目的:

为了研究是否有的对比剂 (Omnipaque) 干扰ATS-13 ADAMTS13活动测试2.0.0.
为了确定Omnipaque是否会导致光体火或影响ADAMTS13酶活性.

主要方法:

评估了单独使用Omnipaque的光谱特性 (激发,发射,吸收) 以及在患者血中.
在已知活性的血样本中评估了ADAMTS13活性,并添加了Omnipaque或盐水对照.
分析的样本在波长范围为250-700 nm.

主要成果:

在Omnipaque样本或250-700nm之间的尖端血中没有检测到非典型的光峰值.
在用Omnipaque增血和用盐水增血之间没有观察到平均ADAMTS13活性的显著差异.
在体外分析表明没有光谱重叠或ADAMTS13的生理抑制由Omnipaque.

结论:

含的对比剂不会干扰基于FRET的ADAMTS13活性测定.
在接受抗剂后怀疑TTP的患者中,不需要推迟ADAMTS13测试.
最近使用类对比剂不应导致不准确的ADAMTS13活性结果.

关键词:

ADAMTS13活动活动在TTP,TTP,TTP中使用.分析变量的分析变量.凝血测试凝血测试凝血测试含有的对比媒介.实验室干扰的干扰在分析前的变量.血栓性血栓细胞低血压性紫外线

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