在疫苗突破性SARS-CoV-2 Omicron感染后,双对应的助推剂和后急性后果的风险:一个队列研究
Liang En Wee1,2,3, Jue Tao Lim1,4, Mayank Goel1
1National Centre for Infectious Diseases, Singapore, Singapore.
概括
与较古老的祖先疫苗相比,更新的双价性COVID-19助推剂显著降低了长期COVID后续的风险,包括神经问题,在Omicron变种感染后.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 接种疫苗可以缓解COVID后的严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 情况.
- 与祖先疫苗相比,对与Omicron相关的后果的双价增强剂疗效的数据有限.
研究的目的:
- 评估双价增强剂是否可以降低感染Omicron变种后COVID后续疾病的风险.
- 在基于人口的队列中,将双价增强剂与祖先疫苗进行比较.
主要方法:
- 一个基于人口的队列研究,使用国家数据库.
- 分析了在Omicron流行期间感染的成年人.
- 竞争风险回归比较了双价和祖先mRNA助推组之间的结果.
主要成果:
- 双价增强剂显示,任何后COVID后续的风险降低37.8%,神经后续的风险降低39.9%.
- 观察到血栓,神经,运动和自身免疫疾病的风险降低.
- 用双价增强剂观察到的每1000个个体的余生负担较低.
结论:
- 双对应的mRNA增强剂在Omicron感染后对COVID后的后续病变提供了更大的保护.
- 更新后的助推剂与各种长期COVID疾病的风险降低有关.
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