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Updated: May 12, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

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利索卡巴基因maraleucel用于复发/耐药的大B细胞淋巴瘤:一个细胞治疗联盟的现实世界分析

Peter A Riedell1, Connor B Grady2, Loretta J Nastoupil3

  • 1David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL.

Blood advances
|December 10, 2024
PubMed
概括

利索卡巴丁基马拉利乌塞尔 (利索细胞) CAR T细胞疗法在现实世界复发/耐药的大B细胞淋巴瘤患者中显示出有效的结果. 这种标准治疗方法的安全性和疗效与临床试验相提并论,即使是在年长,病情较重的个体中.

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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