甲索特雷克萨特治疗期间血压变化:在心血管风险患者中随机 Placebo 控制试验的结果
Jing Cui1, Paul M Ridker2, Daniel H Solomon1
1Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Rheumatology (Oxford, England)
|December 10, 2024
概括
低剂量甲状腺素 (LD-MTX) 在患有心血管疾病但没有类风湿病的患者中没有显著降低血压. 这项研究发现LD-MTX和安慰剂组之间血压没有临床意义上的差异.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 低剂量甲状腺素 (LD-MTX) 与风湿性疾病中的心血管疾病 (CVD) 风险降低有关.
- 以前的研究表明LD-MTX可能会降低血压 (BP).
- 在非风湿性疾病患者群体中LD-MTX对血压的影响尚不清楚.
研究的目的:
- 为了研究LD-MTX对血压 (BP) 的影响.
- 评估已知心血管疾病但没有类风湿性疾病的患者接受LD-MTX与安慰剂的血压变化.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的临床试验.
- 在平均26个月的随访期内监测了缩和腹血压 (SBP,DBP).
- 线性混合模型被用来比较LD-MTX和安慰剂组之间的血压变化.
主要成果:
- 该研究包括LD-MTX手臂的2391名患者和安慰剂手臂的2395名患者.
- 与安慰剂相比,LD-MTX显示SBP (β = -0.75 mmHg) 和DBP (β = -0.56 mmHg) 的小,统计学上显著的减少.
- 这些变化不被认为具有临床意义.
结论:
- 与安慰剂相比,LD-MTX在患有心血管疾病但没有类风湿性疾病的患者中没有导致临床意义上的血压差异.
- 这些发现不支持仅在该人群中使用LD-MTX降低血压.
相关概念视频
Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Measurement of Blood Pressure
871
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
871
Errors occurring during blood pressure monitoring
601
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
601
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
385
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
385
Alterations in Blood Pressure
1.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.2K
Blood Pressure
998
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
998


