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Leonard E Bäcker1, Kevin Broux1, Louise Weckx1

  • 1Department of Microbial and Molecular Systems, Faculty of Bioscience Engineering, KU Leuven, Kasteelpark Arenberg 23-bus 2457, 3001 Leuven, Belgium.

Nucleic acids research
|December 10, 2024
PubMed
概括

研究人员在细菌中设计了一种合成遗传电路,用于自主,可调节的细胞功能的时间控制. 该系统可实现编程的生产-溶解周期和生物处理和治疗应用的种群异质性.

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The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
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