在儿科创伤中提升预后预测:炎症标记物的作用
Abdulrahman Özel1, Servet Yuce2, Esra Nur Ilbegi3
1Pediatric İntensive Care Unit, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey.
Klinische Padiatrie
|December 10, 2024
概括
乳酸与白蛋白比率 (LAR) 和前素 (PCT) 有效预测儿科创伤患者的死亡率. 这些标志物和其他标志物一起,可以在PICU中识别高风险儿童.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 创伤外科 手术 创伤外科
- 炎症生物标志物 炎症生物标志物
背景情况:
- 儿童创伤患者入院于PICU面临显著的死亡风险.
- 确定可靠的预后标志物对于及时干预至关重要.
研究的目的:
- 评估炎症标志物的预后价值和完整的血清衍生指数,用于预测儿科创伤患者的死亡率.
- 为了确定风险分层的独立和组合标记.
主要方法:
- 一项对165名儿童创伤患者在PICU的回顾性研究.
- 分析各种炎症标志物,包括乳酸与白蛋白比率 (LAR),前素 (PCT),系统性免疫炎症指数 (SIRI),中性粒细胞与淋巴细胞比率 (NLR),CRP与白蛋白比率 (CAR) 和泛免疫炎症值 (PIV).
主要成果:
- 死亡率为5.45%,其中死亡率为5.45%.
- 在死亡率方面,LAR (AUC 0.807) 和PCT (AUC 0.745) 的预后表现强.
- LAR和PCT与死亡率,机械通风持续时间和PICU停留相关.
结论:
- LAR和PCT是可靠的独立标志物,用于预测重症儿科创伤患者的死亡率.
- 虽然其他指数如SIRI,NLR,CAR和PIV的个体有效性较低,但它们在组合中可能具有价值.
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