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Updated: Jul 1, 2026

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
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由外源性Neurexin-1诱导的神经元类谱系差异化作为质瘤潜在的治疗策略

Chihyi Liao1, Yankun Chen2, Dazhao Peng2

  • 1Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Cancer letters
|December 10, 2024
PubMed
概括

增强神经元分化基因可以改善质瘤的预后. 神经素-1 (NRXN1) 促进神经元细胞命运,减少恶性瘤,并改善多种质母细胞瘤 (GBM) 的结果.

关键词:
癌症干细胞是一种癌症干细胞.细胞相互作用 细胞相互作用差异化疗法是不同的疗法.质瘤是一种质瘤.神经素-1-1 的使用.

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...