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Updated: Jun 5, 2025

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建立基于历史重复剂量数据的药物中间体毒理关注的门,并将其应用于设定基于健康的暴露限值

Zoe Dunn1, Delorice Murudzwa2, Kamila Blum3

  • 1GSK, Health Hazard Assessment, Environment Health Safety (EHS), Stevenage, United Kingdom.

Regulatory toxicology and pharmacology : RTP
|December 10, 2024
PubMed
概括

制药中间体 (IM) 的有限毒理数据阻碍了基于健康的暴露限值 (HBEL) 的计算. 为IMs提出的默认HBEL有助于工人和患者的安全,支持未来的数据放弃.

关键词:
基于健康的暴露限值 (HBEL)中介产品 (IM) 是指中间产品.职业暴露限值 (OEL) 是指职业暴露的极限值.允许的每日暴露 (PDE)重复剂量毒性 (RDT) 是指重复剂量毒性.有毒性关注的门 (TTC)

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