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用低度布틸帕拉本长期治疗对前列腺器官的作用
Yujin Hwang1, Yejin Kim1, Dongkyu Choi2
1Department of Food Science and Biotechnology, Gachon University, Seongnam, Gyeonggi-do, 13120, Republic of Korea.
Environmental pollution (Barking, Essex : 1987)
|December 10, 2024
概括
长期暴露于低剂量布틸帕拉本 (BP),一种常见的防腐剂,会破坏男性前列腺荷尔蒙并增加氧化应激. 前列腺有机体表现出保护性抗氧化反应,突出显示了它们作为替代研究模式的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 干扰内分泌的化合物 (EDC) 如丁 (BP) 在消费品中普遍存在,并与男性生殖健康问题有关.
- 前列腺特别容易受到EDC引起的荷尔蒙失衡,可能导致疾病.
- 有限的研究存在于低剂量BP暴露的长期影响,依赖于体外方法.
研究的目的:
- 调查低剂量丁甲 (BP) 暴露对前列腺组织的长期影响.
- 为了更准确地评估EDC风险,利用前列腺器官模型.
- 为了评估荷尔蒙平衡,氧化应激和细胞对高血压的反应.
主要方法:
- 前列腺器官在长时间内暴露于低剂量的BP.
- 分析了激素受体表达,以评估激素失衡.
- DCFDA染色用于检测反应性氧物种 (ROS) 生产.
- 进行了转录组分析和测量了抗氧化因子蛋白水平.
主要成果:
- 长期暴露于血压导致前列腺器官中的荷尔蒙失衡,由改变的荷尔蒙受体表达体现出来.
- 观察到ROS产量的增加,表明氧化应激.
- 前列腺有机体通过上调抗氧化因子来表现出一种保护机制.
- 转录组分析证实了BP诱导的生殖毒性.
结论:
- 长期,低剂量的BP暴露会导致前列腺器官的荷尔蒙干扰和氧化应激,导致生殖毒性.
- 前列腺有机体表现出涉及抗氧化因子表达的固有保护机制.
- 前列腺器官可作为动物模型的替代品来研究EDC对男性生殖健康的影响.
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