基于多电解质复合物的比格尔作为阴道药物输送系统
Raúl Cazorla-Luna1, Fernando Notario-Pérez2, Araceli Martín-Illana1
1Departamento de Farmacia Galénica y Tecnología Alimentaria, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n 28040, Madrid, Spain.
International journal of pharmaceutics
|December 10, 2024
概括
新的基托基大形成多电解质复合物,用于在阴道环境中独立于pH的药物释放. 这些多功能的大豆提供调节性质,改进了当前的阴道药物输送系统.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 准备了含有阴性奇托和阳性聚合物 (卡拉雅,pectin,xanthan) 的比格尔.
- 这些聚合物之间形成的多电解质复合物改变了BIGEL的特性.
- 经冷干燥的大牛被测试了阴道环境条件.
研究的目的:
- 在模拟的阴道条件下评估大牛的胀和药物释放概况.
- 调查聚电解质复合体形成对药物释放的影响.
- 评估聚合物组成对比格尔性质和粘粘度的影响.
主要方法:
- 使用奇托和离子聚合物制备大面包.
- 冰干燥的大牛肉.冷干燥的大牛肉.
- 在模拟的阴道介质 (正常和射精后) 中评估胀和药物释放.
主要成果:
- 聚电解质复合物的形成导致了pH值独立的持续药物释放.
- 一种聚合物占主导地位导致了依赖pH值的药物释放,这在治疗上可能有用.
- 增加的基托桑含量改善了机械性能;增加的阳离子聚合物增强了粘粘性.
结论:
- 开发出来的大提供可调节的物理化学特性,用于阴道药物输送.
- 聚电解质复合物的形成是实现pH独立持续释放的关键.
- 这些多用途的Bigel系统比现有的阴道药物输送配方具有优势.
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