在中国丽水市爆发的Campylobacter jejuni疫情的流行病学和基因组特征
Yumei Ge1,2, Youqi Ji1,2, Jianhua Mei3
1Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Foodborne pathogens and disease
|December 10, 2024
概括
一个罕见的Campylobacter jejuni疫情发生在中国一所初中,影响了47名学生. 这项调查确定了ST6913菌株是导致食物传播疾病的原因.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 坎比洛巴克是全球细菌性食物传播腹疾病的主要原因之一.
- 坎皮洛巴克特菌疫情在中国很少被报告,这使得这一事件具有意义.
- 2019年11月,中国东部的一所初中发生了腹疾病的爆发.
研究的目的:
- 为了调查学生中疑似由食物传播的腹疾病的爆发.
- 确定致病原体及其遗传特征.
- 了解这种罕见的坎皮洛巴克特在中国爆发的流行病学.
主要方法:
- 收集了40个样本:24个来自患者的便,12个来自厨房工作人员的便,4个水样.
- 用实时聚合酶链反应 (PCR) 检测多种肠道病原体的选样本.
- 使用脉冲场凝电泳 (PFGE),全基因组测序和抗微生物敏感性测试,对Campylobacter jejuni分离物的特征.
主要成果:
- 在569名学生和教职员工中报告了47例腹病例.
- 实时PCR检测到47个患者便样本中的16个中发现了Campylobacter jejuni.
- 分离的三种C. jejuni菌株显示PFGE与ST6913有100%的相似性,没有基因组变异.
结论:
- 坎皮洛巴克特 (Campylobacter jejuni) ST6913被确定为学校疫情的致病原体.
- 这项研究强调了在中国报告的少数C. jejuni疫情之一.
- 有效的疫情调查和分子排型对于控制食源性疾病至关重要.
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