夜间低氧症对安第斯高地人的认知表现的影响
Elizabeth V Young1, Matea A Djokic1,2, Erica C Heinrich1,3
1Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, California, USA.
High altitude medicine & biology
|December 10, 2024
概括
高海拔生活会导致夜间低氧 (低氧),损害认知功能. 这项研究将更高的夜间低氧化和更高的红细胞计数与安第斯高地人的反应时间较慢和认知缺陷联系在一起.
科学领域:
- 身体生理学 身体生理学
- 神经科学是一个神经科学.
- 高度医学 高度医学
背景情况:
- 安第斯高地人经历慢性低氧症,增加过度红细胞瘤 (EE) 和慢性山病 (CMS) 的易感性.
- 夜间低氧化,比白天更严重,有持续和间歇的组成部分.
- 在这个人群中,与夜间低氧血症相关的认知障碍尚未得到充分研究.
研究的目的:
- 为了研究夜间低氧化和认知功能在永久高海拔居民之间的关系.
- 为了确定血红素的增加是否会加剧与低氧化症相关的认知障碍.
主要方法:
- 48名居住在4,340米的参与者接受了夜间睡眠研究.
- 通过一系列测试来评估认知功能,包括气球模拟风险任务 (BART),情绪识别测试 (ERT) 和Trail Making Task.
- 夜间低氧水平和血红素与认知表现指标相关.
主要成果:
- 较大的夜间低氧症与BART和ERT的更长反应时间相关 (p < 0.01).
- 增加的夜间低氧症与更长的完成时间有关,在Trail Making Task (p = 0.03).
- 较高的血红素水平与ERT和BART的性能受损有关 (p = 0.01).
结论:
- 增加的夜间低氧化和升高的血红素与永久生活在高海拔地区的人的认知表现缺陷有关.
- 这些发现突出了高海拔人口的潜在长期认知风险,并建议了EE和CMS相关的预防策略的途径.
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