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Updated: Jun 5, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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Rh (II) -催化选择性C (sp) -H (C) -H (sp) -H键级联插入以构建 [6-8-6] 子化脚手架

Tao Yu1,2, Feifei Fang3, Haowen Shou1

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.

Organic letters
|December 10, 2024
PubMed
概括

研究人员开发了一种新的一步合成,用于合的八个成员碳循环 (EMC),这对于药物发现至关重要. 这种高效的方法简化了复杂的 [6-8-6] 合基支架的创建,克服了传统的局限性.

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Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism

Birch reduction uses solvated electrons as reducing agents. The reaction converts benzene to 1,4-cyclohexadiene. The reaction proceeds by the transfer of a single electron to the ring to form a benzene radical anion. This anion is highly basic—it abstracts a proton from the alcohol to form a cyclohexadienyl radical. Another single electron transfer gives the cyclohexadienyl anion. A proton transfer from the alcohol forms 1,4-cyclohexadiene. Since this reduction occurs via radical anion...
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