疲劳患者中潜在疾病风险:初级保健中的基于人口的队列研究
Becky White1, Nadine Zakkak2, Cristina Renzi3
1Epidemiology of Cancer Healthcare and Outcomes (ECHO) Research Group, Department of Behavioural Science and Health, Institute of Epidemiology & Health Care, University College London, London, UK.
概括
在初级保健中,新出现的疲劳与许多疾病有关. 疲劳的老年男性患癌症的风险更高,需要优先调查,与女性不同.
科学领域:
- 主要护理药物 医疗保健药物
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 疲劳是一种常见的初级保健症状,原因多种多样,包括癌症等严重疾病.
- 疲劳表现后各种诊断,特别是癌症的相对风险尚未得到充分确立.
研究的目的:
- 量化新发性疲劳与随后的各种疾病诊断之间的联系.
- 具体评估在初级保健环境中疲劳和癌症诊断之间的联系.
主要方法:
- 一项大型队列研究 (2007-2017) 将出现新发性疲劳的患者与没有出现这种疲劳的患者进行了比较.
- 利用临床实践研究数据链接数据,与医院记录和国家癌症登记册联系在一起.
- 对237种疾病进行了模拟的疾病特异性12个月风险和计算的年龄调整风险.
主要成果:
- 分析了超过30万患有疲劳的患者和超过40万没有疲劳的患者.
- 疲劳与男性的127种疾病和女性的151种疾病的发病率增加有关.
- 到80岁时,癌症在疲劳的男性中是第四高的绝对过度风险 (3.65%的过度),但在女性中较少发生.
结论:
- 该研究为表现为疲劳的患者提供了诊断的排名概率.
- 研究结果支持优先考虑70岁及以上男性的癌症调查,这些男性表现出疲劳.
- 仅仅是疲劳并不能证明在任何年龄段的女性中优先进行癌症调查.
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