在神经干预程序的双抗血小板治疗方案中降低提卡格勒的剂量
Amol Mehta1, Preethi Reddi1, S Javin Bose1
1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Journal of neurointerventional surgery
|December 10, 2024
概括
提卡格雷勒60毫克每天两次与阿司匹林一起,对于接受内支架的患者进行双重抗血小板治疗是安全有效的,其安全性与阿司匹林和克洛皮多格雷尔相比,但具有改善的P2Y12抑制和较低的支架狭窄.
科学领域:
- 神经干预手术是一种神经干预手术.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 提卡格勒勒是一种P2Y12抑制剂,是双抗血小板疗法 (DAPT) 的潜在替代品,因为其迅速发作和持续的血小板抑制.
- 对于神经干预手术,提卡格勒的最佳剂量需要进一步研究.
研究的目的:
- 评估Ticagrelor每天两次60毫克和阿司匹林每天81毫克的安全性和有效性,与标准阿司匹林和皮格瑞尔相比,用于内支架.
主要方法:
- 一个回顾性分析的前性维护的数据库的患者接受内支架.
- 治疗Ticagrelor和阿司匹林的患者和治疗阿司匹林和克洛皮多格雷尔的患者之间的结局的比较.
- 主要结局包括30天内手术前的缺血和/或出血事件;次要结局包括P2Y12反应单元和支架内狭窄率.
主要成果:
- 蒂卡格雷勒和克洛皮多格雷尔组之间缺血或出血事件没有显著差异.
- 提卡格雷勒组显示P2Y12反应单位显著降低 (69对126,P<0.001).
- 在提卡格雷勒组中观察到更低的静脉支架狭窄率 (5%对21%).
结论:
- 提卡格雷勒60毫克是一种安全有效的选择,用于DAPT在内支架.
- 建议进行进一步的前性研究来证实这些发现.
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