环境多发性硬化症 (MS) 风险因素,遗传性MS风险,以及一般儿童群体中的大脑发育
Casper Louk de Mol1, Sander Lamballais2, Ryan Muetzel3
1Neurology, MS Center ErasMS, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands.
Journal of neurology, neurosurgery, and psychiatry
|December 10, 2024
概括
遗传和环境因素相互作用,影响儿童的大脑发育,影响多发性硬化症 (MS) 风险. 减少儿童接触家庭吸烟可能有助于预防MS在遗传敏感的个体.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 环境健康 环境健康
背景情况:
- 神经轴损失是多发性硬化症 (MS) 的早期指标.
- 早期神经轴损失 (炎症与神经退行性) 的起源尚不清楚.
- 遗传和环境因素可能会影响MS发病前的神经发育.
研究的目的:
- 研究多发性硬化症遗传和环境风险因素与儿童大脑MRI结果的关联和相互作用.
- 评估基因负担和环境暴露对基于人口的儿童群体神经发育的影响.
主要方法:
- 在一个庞大的儿童队列中,在9岁和13岁时检查了大脑体积和扩散MRI数据.
- 在5岁时使用MS的多基因风险评分 (PRS) 和评估的环境因素 (EBV,维生素D,BMI,户外活动,父母吸烟).
- 分析了MS-PRS,环境因素和脑MRI结果之间的关联和相互作用.
主要成果:
- 在EBV阳性儿童中,MS-PRS与爱斯坦-巴尔病毒 (EBV) 标位正相关.
- MS-PRS显示出与皮下灰质体积的负相关性.
- MS-PRS和家庭家长吸烟之间的相互作用与减少总大脑和胸膜体积有关.
结论:
- 多发性硬化症的遗传和环境风险因素在童年期间相互作用,影响大脑发育.
- 早期暴露在家庭吸烟中,与遗传倾向相结合,与较小的大脑体积有关.
- 针对家庭吸烟等环境因素的干预策略可能为遗传敏感个体的MS提供预防方法.
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