在体外通过皮肤释放的crocin从电沙夫兰和它的比较与体外消化消化
Zahra Najafi1, Filiz Altay1, Neşe Şahin-Yeşilçubuk1
1Istanbul Technical University, Department of Food Engineering, Maslak, 34469 Sariyer, Istanbul, Turkey.
Food research international (Ottawa, Ont.)
|December 10, 2024
概括
沙夫兰提取物 (SE) 已成功封装在纳米纤维中,用于潜在的通过皮肤输送. 这些纳米纤维表现出受控释放,表明它们适用于食补充剂.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 药理学 药理学 是一个学科.
背景情况:
- 沙法兰提取物 (SE) 是一种有价值的营养药,具有潜在的健康益处.
- 开发SE的有效传递系统对于其作为食补充剂的应用至关重要.
- 纳米纤维为控制释放和增强生物利用性提供了一个有希望的平台.
研究的目的:
- 使用pullulan-pectin,pullulan-pea蛋白-pectin和 zein.制造出沙夫兰提取物 (SE) 装载的纳米纤维.
- 为了研究这些纳米纤维的体外透皮透机制和SE的动力学.
- 为了比较SE在体外消化和通过皮肤透过程中的释放概况.
主要方法:
- 带有SE载荷的pullulan-pectin,pullulan-pea蛋白-pectin和 zein纳米纤维的电旋转.
- 减弱总反射里埃变换红外光谱 (ATR-FTIR) 用于相互作用分析.
- 在体外消化研究使用模拟的胃肠液 (SGF,SIF) 和透析袋.
- 采用弗朗茨扩散细胞进行的体外透皮透研究.
- 纳米纤维的湿透性和膨胀率的确定.
- 动力建模 (Ritger-Peppas和Higuchi模型) 的SE发布.
主要成果:
- 普鲁兰-pectin-SE纳米纤维的接触角度最低,胀率最高,导致消化过程中SE释放率最高.
- 瑞格-佩帕斯和希古奇模型有效地描述了消化和透皮透的释放数据.
- 在模拟胃液 (SGF) 中,SE从纳米纤维释放,遵循非Fickian机制.
- 在SGF和所有测试的纳米纤维中,在模拟肠液 (SIF) 和透皮研究中,Fickian扩散控制了从SGF中的基于pullulan的纳米纤维中释放SE的释放.
结论:
- 纳米纤维是有效的控制输送的番茄提取物 (SE).
- 开发的纳米纤维显示了作为食补充剂的跨皮应用的潜力.
- 了解释放机制 (Fickian与非Fickian) 是优化SE交付系统的关键.
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