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乳酸细菌对阿弗拉托辛B1的隔离:结合和生物转化作用

Jenna Lemmetty¹, Youngsun Lee¹, Tiina Laitila¹

¹Department of Food and Nutrition, University of Helsinki, Anges Sjöbergin katu 2, Helsinki 00790, Finland.

Food research international (Ottawa, Ont.)

|December 10, 2024

概括

乳酸细菌 (LAB) 可以减少农作物中阿弗拉托克辛B1 (AFB1) 的污染. 将AFB1结合到LAB细胞,特别是不可活性的LAB细胞,是对其去污染的最有效方法.

科学领域:

食品科学与技术食品科学与技术
微生物学微生物学
毒理学毒理学毒理学

背景情况:

气候变化加剧了食品安全风险,因为农作物中菌毒素污染增加.
非洲毒素B1 (AFB1) 是一种强有力的致癌物,由于其普遍存在,它对健康构成重大风险.
乳酸细菌 (LAB) 正在探索它们在AFB1排毒中的潜力.

研究的目的:

评估各种LAB菌株在减少AFB1污染方面的有效性.
调查LAB减少AFB1.1的主要机制.

主要方法:

使用不同的LAB菌株进行了AFB1结合试验.
通过同时化和LC-QTOF-MS分析来评估LAB对AFB1的生物转化.
通过比较结合效率和生物转化效率来阐明减少的机制.

主要成果:

实验室表明,AFB1显著减少 (16-71%),主要是通过结合,这是菌株特异的和pH取决于.
与活性的细胞相比,非活性的LAB细胞显示出增强的AFB1结合能力.
生物转化导致极小的AFB1减少 (0-18%) 没有检测到的转化产品.

结论:

结合是通过LAB减少AFB1的主要机制,其性能优于生物转化.
特定的LAB菌株,特别是不可活性的LAB菌株,对AFB1的净化策略有很大的希望.
为了提高食品安全,需要对LAB-based AFB1缓解进行进一步的研究.

关键词:

非洲毒素B1是什么?有约束力的约束力生物转化生物转化乳酸细菌是一种乳酸细菌.

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