2022年全球多发性骨髓瘤发病率和死亡率负担以及2045年的预测
Allini Mafra1, Mathieu Laversanne2, Rafael Marcos-Gragera3,4,5,6
1Cancer Epidemiology and Prevention Group (EPI CAN), Department of Precision Health, Luxembourg Institute of Health, Strassen L-1445, Luxembourg.
Journal of the National Cancer Institute
|December 10, 2024
概括
多发性骨髓瘤 (MM) 的病例和死亡人数在全球范围内不断增加,区域差异很大. 预测显示,到2045年,这种恶性血液瘤的数量将大幅增加,因此需要加强对这种恶性血液瘤的监测和疾病控制.
科学领域:
- 血液学的恶性瘤
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 多发性骨髓瘤 (MM) 是一种主要影响老年人的重大血液性恶性瘤,其特点是预后普遍不佳.
- 了解MM的全球发病率和死亡率模式对于公共卫生倡议至关重要.
研究的目的:
- 为了呈现当前的多发性骨髓瘤 (MM) 的全球发病率和死亡率数据.
- 预测到2045年未来的MM病例和死亡人数.
主要方法:
- 利用GLOBOCAN 2022 MM病例和死亡数据库,包括185个国家的年龄标准化率.
- 联合国估计,就业人口将预测到2045年的MM发病率和死亡率趋势.
主要成果:
- 在2022年,全球估计有188,000例MM病例和121,000例死亡. 东亚和北美占病例比例最高.
- 发病率和死亡率在地理位置上有所不同,男性的发病率更高. 北美和澳大利亚/新西兰的发病率最高,而澳大利亚/新西兰,北欧和南非的死亡率最高.
- 如果不进行干预,预计到2045年,MM发病率和死亡率将分别增加71%和79%.
结论:
- 该研究强调了MM发病率和死亡率的巨大全球负担和差异,反映了诊断和治疗方面的不平等.
- 加强监测和改善疾病控制战略对于减轻MM日益增长的全球影响至关重要,特别是随着世界人口的老龄化和增长.
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