GlyT2-阳性神经间神经元调节大脑-行为循环中信息传输的时间和可变性
Ensor Rafael Palacios1,2, Conor Houghton2, Paul Chadderton1
1School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol BS8 1TD, United Kingdom ensorrafael.palacios@bristol.ac.uk p.chadderton@bristol.ac.uk.
概括
小脑中GlyT2阳性内神经元的抑制影响小脑中神经活动的时间. 这种时间控制对于协调运动和下游小脑功能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 小脑生理学 大脑小脑生理学
背景情况:
- 甘氨酸运输体2 (GlyT2) 阳性内部神经元,包括戈尔吉和卢加罗细胞,在小脑皮层的输入层中具有战略位置.
- 这些内部神经元在小脑中调节信息处理方面发挥着至关重要的作用.
研究的目的:
- 调查GlyT2阳性内神经元在小脑网络动态中的贡献,在小鼠的自由鞭打.
- 了解如何改变这些内部神经元的活动会影响感官运动表现和行为.
主要方法:
- 使用Neuropixels探针在老鼠侧向小脑皮层的Crus 1中记录了神经元群活动.
- 在雄性和雌性小鼠中进行了GlyT2阳性内部神经元的化学基因下调.
- 分析的重点是操纵前后的网络活动.
主要成果:
- 在休息条件下,小脑群体活动编码了胡须运动.
- 减少GlyT2阳性细胞活动导致神经活动的轻微增加,而不会显著损害感觉运动表征.
- 来自戈尔吉和卢加罗细胞的抑制减少,在运动开始时增强了局部网络活动的时间对齐.
- 行为影响是可变的,观察到鞭毛速度的增加和减少.
结论:
- 具有GlyT2阳性的内部神经元抑制是小脑群活动时间模式的关键调节者.
- 这种时间控制对于支持下游小脑动态和协调的运动行为至关重要.
- 这些发现突出了这些内部神经元在通过精确的定时机制提炼电机输出中的特定作用.
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