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睡眠和轮班工作对主要免疫反应对基于信使RNA的COVID-19疫苗接种的影响
Tamara M J Brouwers1,2, Ümmü Gülsüm Çobanoğlu3, Daryl Geers4
1Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Journal of sleep research
|December 10, 2024
概括
轮班工作,特别是夜班,导致COVID-19疫苗接种周围的睡眠减少,但没有显著影响抗体反应. 然而,夜班工作者在接种疫苗后表现出更强的T细胞反应.
科学领域:
- 免疫学 免疫学 免疫学
- 睡眠医学 睡眠医学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 轮班工作扰乱昼夜节律,可能影响免疫功能和疫苗反应.
- 了解轮班工作对接种疫苗的原发性免疫反应的影响对于公共卫生至关重要.
研究的目的:
- 为了比较SARS-CoV-2特定的幽默和细胞免疫反应对mRNA-1273疫苗接种在白天和夜班工作者.
- 研究轮班工人睡眠时间,质量和疫苗免疫性之间的关系.
主要方法:
- 在日勤工人 (n=24) 和夜勤工人 (n=21) 中,mRNA-1273疫苗接种后的抗体和T细胞反应的比较.
- 在接种疫苗后7天内,使用动图和睡眠日记评估睡眠时间和质量.
- 多变量回归分析以确定睡眠参数与免疫反应之间的关联.
主要成果:
- 与白天工作者相比,夜班工作者在接种疫苗周围的日子里睡眠时间明显较短 (p < 0.001).
- 两组之间没有观察到抗体反应的显著差异.
- 晚班工作者在接种疫苗后28天表现出明显更高的病毒特异性T细胞反应 (p = 0.013).
- 睡眠时间和质量与SARS-CoV-2特定免疫反应无关.
结论:
- 轮班工作引起的睡眠丧失和夜班工作对基于mRNA的COVID-19疫苗接种的初级免疫反应产生了很小或没有负面影响.
- 虽然睡眠减少,但在接种疫苗后,夜班工作者可能会增强细胞免疫反应.
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