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[用于预防化疗引起的外围神经病变的电:随机对照试验]

Yao Yao¹, Xiping Zhang¹, Renjie Ge¹

¹Department of Breast Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

|December 10, 2024

概括

在乳腺癌患者中,电显著降低了化疗诱导的周围神经病变 (CIPN) 的发生率和严重程度. 这种治疗还可以改善神经功能,提高患者的生活质量.

科学领域:

综合性瘤学综合性瘤学
神经学神经学
癌症护理癌症护理

背景情况:

化疗诱导的周围神经病变 (CIPN) 是一种常见的剂量限制性毒性.
现有的CIPN治疗方法的疗效有限.
需要新的策略来预防和管理CIPN.

研究的目的:

评估电针 (EA) 在预防CIPN的临床有效性.
评估EA对接受化疗的患者神经传导和生活质量的影响.

主要方法:

一项随机对照试验,涉及52名接受基于税的化疗的乳腺癌患者.
患者被分配到电针 (EA) 加常规护理 (UC) 或单独UC.
结果包括CIPN发生率,严重程度,神经传导速度 (SCV,MCV) 和生活质量 (EORTC QLQ-CIPN20,EORTC QLQ-C30,TCM规模).

主要成果:

在EA组中,CIPN的发病率明显较低 (17.4%),相比于UC组 (72.0%) 在24周 (P<0.001).
高度CIPN发生率在EA组为0%,在UC组为28.0% (P<0.05).
EA提高了感觉神经传导速度,降低了CIPN症状得分,对生活质量指标产生了积极影响.

结论:

电是一种有效的干预措施,可以减少CIPN的发生率和严重程度.
EA在保护神经功能和改善接受化疗的癌症患者的生活质量方面显示出潜力.

关键词:

乳腺癌乳腺癌乳腺癌化疗诱导的外周神经病变电针是一种电针.随机对照试验 (RCT) 是一种随机对照试验.

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