IL-23R是一种与衰老相关的循环和组织生物标志物,是衰老的生物标志物
Chase M Carver1,2, Sonia L Rodriguez1,2, Elizabeth J Atkinson3
1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Nature aging
|December 10, 2024
概括
衰老药物可以逆转衰老的生物标志物,并揭示循环因素,这些因素在各器官中信号衰老. 这项研究确定了受老化和老年疗法影响的关键蛋白质和转录.
科学领域:
- 老年学是一门学科.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 细胞衰老,以细胞循环停止和SASP为标志,是衰老的标志.
- 针对衰老细胞的老化药物在临床前模型中对与年龄相关的疾病显示出有前途.
- 不同的老年化药物在活体中对衰老生物标志物的比较有效性仍未得到充分研究.
研究的目的:
- 为了识别与衰老和衰老相关的血蛋白和组织转录.
- 为了比较不同的老化药物的疗效和老年小鼠的转基因老化细胞清除.
- 研究循环因素作为系统衰老细胞负担的生物标志物.
主要方法:
- 在年轻小鼠和老小鼠中建立了与衰老相关的血蛋白和组织转录档案.
- 对老年小鼠进行了venetoclax,navitoclax,fisetin或luteolin的急性治疗.
- 利用转基因p16-InkAttac小鼠进行衰老细胞清除比较.
- 在人类一生中分析了血IL-23R水平.
主要成果:
- 在血蛋白 (IL-23R,CCL5,CA13) 和组织转录中发现了年龄相关的变化.
- 老年治疗药物逆转了年龄相关的血蛋白变化,特别是影响脏基因表达.
- 在人类中观察到与年龄相关的血IL-23R增加.
结论:
- 老年疗法可以逆转与衰老相关的血蛋白变化,并影响组织表达.
- 像IL-23R这样的循环因子是与衰老相关的器官间信号传递的潜在媒介.
- 确定了系统衰老细胞负担的翻译相关生物标志物.
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