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Updated: Jun 5, 2025

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在肺腺癌中,TFF3驱动Hippo依赖的EGFR-TKI耐药性

Shuwei Zhang1, Yan Qin Tan1,2, Xi Zhang3

  • 1Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China.

Oncogene
|December 10, 2024
PubMed
概括

三叶草因子3 (TFF3) 在肺腺癌 (LUAD) 中驱动对表皮生长因子受体 (EGFR) 氨酸激酶抑制剂 (TKI) 治疗的耐药性. 抑制TFF3可以克服这种耐药性,改善LUAD治疗结果.

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Regulation of Angiogenesis and Blood Supply01:24

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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