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Updated: May 12, 2026

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在早期心脏发育过程中,PDGFRA是一种保存的HAND2效应器

Yanli Xu1, Rupal Gehlot1, Samuel J Capon1

  • 1Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

Nature cardiovascular research
|December 10, 2024
PubMed
概括

转录因子HAND2对于心脏发育至关重要. 在心脏发生过程中,DNA结合,而不是二元化,对于HAND2功能至关重要,PDGFR-alpha被确定为一个关键的下游效应因子.

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Activation and Inactivation of G Proteins01:22

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Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high affinity and are together...