分量流量储备测量的基于性别的特点
Fabio Mangiacapra1,2, Gabor G Toth3, Luca Paolucci1,2
1Research Unit of Cardiovascular Science, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
概括
女性患者的分量流量储备 (FFR) 值比男性高. 50%的直径狭窄 (DS) 最好在两性中确定显著的冠状动脉疾病,尽管更高的门提高了女性的分类.
科学领域:
- 心血管医学 心血管医学
- 干预性心脏病学 干预性心脏病学
- 诊断成像诊断成像的使用
背景情况:
- 基于性别的冠状动脉血管检测结果和分数流量储备 (FFR) 之间的关系尚未得到充分理解.
- 评估冠状动脉狭窄的严重程度需要准确的方法,以进行解剖学和功能评估.
研究的目的:
- 调查冠状动脉血管学和FFR测量之间的协议中的基于性别的差异.
- 为了确定血管学参数是否预测冠状动脉狭窄症的功能意义在男性和女性中不同.
主要方法:
- 分析了来自稳定患者的3770例冠状动脉狭窄症,这些患者接受了定量冠状动脉血管造影和FFR测量.
- 使用接收器操作特征 (ROC) 分析,比较直径狭窄 (DS) 值,以预测性别之间的缺血性FFR值.
主要成果:
- 与男性 (0.81) 相比,女性 (0.84) 的FFR值中位数较高.
- 一个50%的DS是最佳的,以确定在两个性别的功能性显著的狭窄.
- 较高的DS值 (≥59%) 改善了女性的病变分类,但增加了虚假阴性.
结论:
- 与男性患者相比,女性患者在各种直径狭窄 (DS) 水平上表现出更高的FFR值.
- 50%的DS值有效地识别男性和女性的功能显著冠状动脉狭窄症.
- 虽然更高的DS值提高了女性的分类,但其代价是增加了虚假阴性结果.
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