种族和种族疾病 现象型差异是由遗传学驱动的: 没有
1Los Angeles Medical Center, Department of Neurology, Southern California Permanente Medical Group, Los Angeles, CA, USA.
Multiple sclerosis (Houndmills, Basingstoke, England)
|December 11, 2024
概括
多发性硬化症 (MS) 影响黑人最多,残疾更快,死亡率更高. 这些差异源于社会因素,如体现的种族主义,而不是遗传,突出显示了环境对MS的影响.
科学领域:
- 神经免疫学 神经免疫学
- 社会流行病学 社会流行病学
- 健康差异 在健康上的差异
背景情况:
- 多发性硬化症 (MS) 在美国的种族和民族群体中发生率,流行率和预后存在显著差异.
- 与白人相比,黑人患上MS的发病率和流行率最高 (尤其是35岁以下),残疾累积速度更快,死亡率更早.
- 虽然MS在西班牙裔和亚洲/太平洋岛民人口中比白人更少,但在年轻的西班牙裔和白人 (25岁以下) 中也观察到类似的患病率.
研究的目的:
- 调查美国多发性硬化症 (MS) 易感性和预后观察到的种族和民族差异背后的原因.
- 批判性地评估遗传学与环境和社会因素在解释这些健康不平等方面的作用.
- 提出体现的种族主义作为MS结果差异的主要解释.
主要方法:
- 审查和综合现有关于多发性硬化症发病率,流行率和结果的流行病学数据,按种族和种族分层.
- 在MS的背景下,对种族和民族的生物学和社会定义的分析.
- 检查已知的MS环境风险因素,包括爱斯坦-巴尔病毒 (EBV) 感染和儿科肥胖症.
主要成果:
- 多发性硬化症的易感性和预后不是由基因决定的,因为种族和种族是社会结构,而不是生物学区别.
- 环境因素,如爱斯坦-巴尔病毒 (EBV) 感染和儿科肥胖症,是MS易感性的主要因素.
- 体现的种族主义为不同种族和种族群体在MS结果中观察到的差异提供了更合理的解释.
结论:
- 在多发性硬化症中观察到的种族和民族差异主要是由社会决定因素和环境暴露驱动的,而不是遗传倾向.
- 具体的种族主义被认为是导致MS和其并发症在黑人社区的不成比例高负担的一个重要因素.
- 未来的研究和干预应集中于解决系统不平等和环境因素,以减轻MS差异.
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