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从FAPI和FDG PET/CT获得的半定量肌肉参数,用于评估患有恶性瘤的患者的肉症
Yang Chen1, Qing Zhang1, Yinting Hu1
1PET Center, Department of Nuclear Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University.
Nuclear medicine communications
|December 11, 2024
概括
纤维细胞激活蛋白抑制剂 (FAPI) PET/CT在评估癌症患者的肉症方面比氧糖 (FDG) PET/CT更有效. 标志性肌肉吸收两种标志物的减少的特征是sarcopenia,在41.7%的患者中普遍存在.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 核医学就是核医学.
背景情况:
- 癌症患者常见的一种并发症是萨尔科佩尼亚,它会影响治疗结果.
- 准确评估sarcopenia对于个性化癌症护理至关重要.
研究的目的:
- 为了比较纤维细胞激活蛋白抑制剂 (FAPI) PET/CT和氧葡萄糖 (FDG) PET/CT在评估患有恶性瘤的患者的麻症时的疗效.
- 通过使用PET/CT识别用于检测肉症的成像生物标志物.
主要方法:
- 对127名接受18F/68Ga-FAPI和18F-FDGPET/CT扫描的癌症患者进行了回顾性分析.
- 测量骨肌面积和L3水平的指数,以诊断肉症.
- 从两种PET/CT模式中分析了肉类和肌肉标准化吸收值 (SUVmax,SUVmean) 之间的关联.
主要成果:
- 在41.7%的患者中存在类.
- 下肌肉SUVmax和SUVmean在FAPI PET/CT上,以及FDG PET/CT上的下肌肉SUVmax,与更高的肉类的患病率有关.
- 与FDG PET/CT (AUC=0.642) 相比,FAPI PET/CT在评估萨尔科佩尼亚的曲线下的面积 (AUC=0.764) 更高.
结论:
- 萨科佩尼亚与FAPI和FDG的肌肉吸收减少有关.
- 与FDG PET/CT相比,FAPI PET/CT是对癌症患者的肉症评估更有前途的成像工具.
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