在患有胃食道逆流病的患者中,焦虑和逆流症状之间的关联:前性队列研究
Michaela Henning1, Katharina Lindgen2, Desiree Paul3
1Department of Psychosomatics and Psychotherapy, University Hospital Cologne, University of Cologne, Cologne, DEU.
Cureus
|December 11, 2024
概括
患有胃食道逆流性疾病 (GERD) 的患者中,焦虑和抑郁是常见的,严重恶化了胃灼热和消化不良等症状. 有效的多学科治疗策略对于管理这些相互关联的疾病至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 临床医学 临床医学
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种普遍存在的胃肠道疾病,其特点是胃灼热,吐和消化不良等症状.
- 患有GERD的患者通常会因为其反流症状的严重性而经历严重的痛苦.
- GERD的心理影响,特别是焦虑和抑郁,需要进一步研究.
研究的目的:
- 为了确定诊断为GERD的患者焦虑和抑郁的患病率.
- 评估焦虑和抑郁之间的相关性以及GERD症状的严重程度,包括DeMeester评分.
- 为了确定患有更高程度心理困扰的患者子组.
主要方法:
- 一项前性队列研究,涉及德国科隆大学医院的458名GERD患者.
- 诊断程序包括上部胃肠道内镜,24小时pH阻抗测试和高分辨率计量以确定DeMeester得分.
- 心理测量评估使用医院焦虑和抑郁量表 (HADS) 来量化焦虑和抑郁水平.
主要成果:
- 观察到心理困扰的高患病率,44.1%的患者表现出高焦虑得分,23.8%的患者表现出高抑郁得分 (HADS>7).
- 没有立即进行手术的患者代表了最痛苦的亚组,其中很大一部分报告高焦虑.
- 焦虑和抑郁症得分升高与GERD症状的严重程度增加显著相关,包括心烧,腹和消化不良.
结论:
- 患有GERD的患者表现出大量的焦虑,这与症状严重程度有关.
- 抑郁症也与反流症状的严重程度存在部分关联.
- 这些发现强调了需要采用综合,多学科的治疗方法,解决GERD的胃肠道和心理方面.
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