早期暴露于EDCs的神经内分泌和发育影响
Madeline Streifer1, Lindsay M Thompson1, Skylar A Mendez1
1Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, TX 78712, USA.
Journal of the Endocrine Society
|December 11, 2024
概括
早期接触多双 (PCB) 会改变大鼠的神经内分泌发育,导致微妙的发育变化和性别特异性的荷尔蒙影响,表明潜在的长期健康风险.
科学领域:
- 环境毒理学环境毒理学
- 神经内分泌学神经内分泌学
- 发育生物学是发展生物学.
背景情况:
- 多双 (PCB) 是具有内分泌干扰性质的全球环境污染物.
- 由于神经内分泌系统发育的脆弱性,围产期接触PCB尤其令人担忧.
- 由于潜在的不良影响,评估PCB暴露影响具有挑战性.
研究的目的:
- 为了研究Aroclor 1221 (A1221),一种雌激素PCB混合物,对KNDy和kisspeptin神经元的发育效应.
- 评估对下丘脑-垂体-淋巴腺 (HPG) 激素和产后发育的影响.
- 检查下丘脑中关键神经内分泌标记物的基因表达.
主要方法:
- 在生命早期向大鼠施用Aroclor 1221 (A1221).
- 进行了RNAscope用于kisspeptin,prodynorphin,神经素B和雌激素受体α基因表达.
- 测量了体重,生理指数,青春期开始,以及血清激素水平 (LH,FSH,雌激素).
主要成果:
- 早期的PCB暴露导致了体重和生理指数的轻微但显著变化.
- 观察到血清LH,FSH和雌激素的性别特异性,年龄相关的变化.
- 雄性大鼠AVPV中增高的普罗迪诺芬表达;对基斯佩丁或神经素B没有影响.
- 与其他哺乳动物相比,观察到KNDy神经元共同表达模式的物种差异.
结论:
- 早期的PCB暴露可以诱导发育和荷尔蒙的变化.
- 这些发现,结合已知的潜在效应,表明不良内分泌和神经行为结果.
- 强调了解PCB对神经内分泌发育和HPG轴功能的影响的重要性.
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