肠道微生物群的变化与比格尔犬辐射诱导的血液损伤相关
Zongyu Huang1,2, Likun Wang1, Jianghui Tong1
1State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Fengtai, Beijing 100071, China.
International journal of microbiology
|December 11, 2024
概括
狗的急性辐射综合征显著改变了肠道细菌,增加了Firmicutes与Bacteroidetes的比率. 虽然血细胞数量恢复,但肠道微生物组的变化仍然存在,这表明辐射损伤的潜在生物标志物.
科学领域:
- 微生物学 微生物学
- 血液学 血液学 血液学
- 辐射生物学 辐射生物学
背景情况:
- 辐射对肠道微生物群的影响及其与血液学损伤的联系尚未完全理解.
- 急性辐射综合征 (ARS) 在预测和管理辐射引起的损害方面提出了复杂的挑战.
研究的目的:
- 在狗模型中研究肠道微生物群的纵向动力学和在暴露于亚致死的玛辐射后的血液学变化.
- 确定与ARS进展和恢复相关的潜在微生物生物标志物.
主要方法:
- 使用2.5 Gy的60Co-γ射线辐射开发了一种ARS的 beagle模型.
- 在45天内监测肠道微生物组合和血液学参数的纵向变化.
- 利用便元基因组学和KEGG通路分析来评估微生物的变化和功能.
主要成果:
- 辐射暴露导致淋巴细胞,中性粒细胞和血小板的急剧下降,Firmicutes/Bacteroidetes比率显著增加.
- 血液学参数在辐射后14天达到最低点,并逐渐恢复,而肠道微生物群结构没有恢复.
- 特定的细菌属 (例如,链球菌,乳杆菌) 增加,而其他 (例如,Prevotella,Bacteroides) 减少;26个KEGG通路被显著改变.
结论:
- 在犬类中,急性辐射暴露后,肠道微生物组合被显著破坏,尽管血液恢复,但持续变化.
- 特定的微生物种与血液学参数相关,表明它们作为不同ARS阶段生物标志物的潜力.
- 了解这些动态为管理辐射伤害和开发诊断工具提供了洞察力.
相关概念视频
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...