Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Interpretable deep convolutional model for nonlinear multivariate time series in complex systems.

Chaos (Woodbury, N.Y.)·2026
Same author

Feasibility of single-beat detection of ventricular late potentials on standard ECG leads via interpretable gradient boosting.

Computer methods and programs in biomedicine·2026
Same author

Cascading 58mer Alpha Satellite superHOR in Complete Orangutan Y Chromosome.

International journal of molecular sciences·2025
Same author

Precise Identification of Higher-Order Repeats (HORs) in T2T-CHM13 Assembly of Human Chromosome 21-Novel 52mer HOR and Failures of Hg38 Assembly.

Genes·2025
Same author

Neuroblastoma Breakpoint Family 3mer Higher Order Repeats/Olduvai Triplet Pattern in the Complete Genome of Human and Nonhuman Primates and Relation to Cognitive Capacity.

Genes·2025
Same author

Maximal Genetic Code Symmetry Is a Physicochemical Purine-Pyrimidine Symmetry Language for Transcription and Translation in the Flow of Genetic Information from DNA to Proteins.

International journal of molecular sciences·2024
Same journal

Correction to: Pathogenicity patterns in cytochrome P450 family.

Bioinformatics advances·2026
Same journal

Region-aware bridge modeling enables interpretable mesoscale representation of spatial transcriptomic tissue sections.

Bioinformatics advances·2026
Same journal

Microbiome differential abundance methodologies to detect relevant taxa associated with chemotherapy toxicity rate in colorectal cancer.

Bioinformatics advances·2026
Same journal

maldipickr dereplicates microbial MALDI-TOF spectra to facilitate multiplexed isolation.

Bioinformatics advances·2026
Same journal

RAM-MSA: an anytime memory-bounded method for exact multiple sequence alignment using path finding.

Bioinformatics advances·2026
Same journal

Interpretable machine learning for low-sample multi-omics: a case study of ferret vaccine response.

Bioinformatics advances·2026
查看所有相关文章

相关实验视频

Updated: Jun 5, 2025

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.6K

高效的基因组单体高阶结构注释和识别使用GRMhor算法.

Matko Glunčić1, Domjan Barić1, Vladimir Paar1,2

  • 1Faculty of Science, University of Zagreb, Zagreb 10000, Croatia.

Bioinformatics advances
|December 11, 2024
PubMed
概括
此摘要是机器生成的。

GRMhor算法在人类中心层高阶重复 (HOR) 结构中发现了显著的差异,显示出比预期的更大的基因组分歧. 这种工具对于分析重复的DNA序列和理解基因组进化至关重要.

更多相关视频

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.3K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.7K

相关实验视频

Last Updated: Jun 5, 2025

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.6K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.3K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.7K

科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 进化生物学 进化生物学

背景情况:

  • 高级重复 (HORs) 对染色体完整性和基因调节至关重要.
  • 识别HOR对于理解基因组进化,染色体分离和疾病至关重要.

研究的目的:

  • 应用GRMhor算法来自动识别HOR结构.
  • 分析人类和高级灵长类动物基因组中的中心区域.

主要方法:

  • 全球重复地图 hor (GRMhor) 算法的应用.
  • 在三个人类基因组中分析20号染色体的中心区域.
  • 在三个高级灵长类动物基因组中对中心区域进行比较分析.

主要成果:

  • 在人类中位素中发现了六种不同的HOR阵列,其复制数和结构有意想不到的变化.
  • 在高级灵长类动物基因组中发现了显著不同的HOR序列,这表明基因组分歧更大.
  • 证明了GRMhor算法在分析个体基因组特异性和重复元素方面的有效性.

结论:

  • GRMhor算法是研究复杂的重复基因组区域的强大工具,特别是中间体.
  • 人类的中心体HOR表现出比预期的更大的多样性,影响我们对人类遗传学的理解.
  • 人类和高级灵长类动物之间的基因组分歧比以前认识到的要大得多,特别是在重复的序列中.