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Updated: Jun 5, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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Published on: June 23, 2019

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合成,表征,生物活动,和计算研究的皮拉佐利-亚醇衍生物的thiophene衍生物

Seema K Bhagwat1, Tushar Janardan Pawar2, Sayali A Kulkarni1

  • 1Department of Chemistry, Research Centre HPT Arts and RYK Science College (Affiliated to S. P. Pune University) Nashik 422005 Maharashtra India.

RSC advances
|December 11, 2024
PubMed
概括

研究人员合成了烯的新型pyrazolyl-thiazole衍生物,证明了强大的抗微生物和抗氧化活性. 这些化合物显示出作为多功能治疗剂对各种细菌和真菌菌株的承诺.

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Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom,...
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Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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