在中国人群中,遗传多态度与妊娠期糖尿病易感性之间的关联
Qiaoli Zeng1,2,3, Jia Liu1,2,3, Xin Liu1,2,3
1Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China.
Frontiers in endocrinology
|December 11, 2024
概括
在中国妇女中,HHEX,IGF2BP2和FTO的遗传变异与妊娠期糖尿病 (GDM) 风险有关. 特定的多形态,特别是在老年母亲 (≥30岁) 中,显示出与增加GDM风险的显著关联.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 生殖内分泌学 生殖内分泌学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在不同人群中,关于HHEX,IGF2BP2和FTO基因多态和妊娠糖尿病 (GDM) 风险之间的关联存在不一致的发现.
- 在特定族群 (如中国人) 中研究这些遗传关联对于了解疾病病因至关重要.
研究的目的:
- 研究HHEX,IGF2BP2和FTO基因中的特定遗传多态化与中国人群中发展GDM的风险之间的关联.
- 确定可能预测GDM易感性的潜在遗传标记,特别是在与母亲年龄有关的情况下.
主要方法:
- 包括IGF2BP2 (rs11705701,rs4402960),FTO (rs9939609) 和HHEX (rs1111875,rs5015480) 在内的单核酸多态 (SNPs) 的基因定型使用SNPscanTM基因定型试验进行.
- 统计分析,包括后勤回归和千平方测试,用于评估基因型和异位基因与GDM风险的关联.
- 单向ANOVA用于比较临床参数,如血糖水平,妊娠周和新生儿体重.
主要成果:
- HHEX rs1111875多态 (异卵性和过度主导模型) 和HHEX rs5015480 (过度主导模型) 与增加GDM风险显著相关,特别是在30岁或以上的女性中.
- 在同一个年龄组 (≥30岁) 中,FTO rs9939609变异 (异子,主导和过度主导模型) 也显示出与高GDM风险的显著关联.
- rs1111875的TC基因型与更高的1小时血糖水平有关,而IGF2BP2 rs11705701的A基因与一般糖尿病风险增加有关.
结论:
- 特定的遗传多态,特别是HHEX rs1111875和rs5015480和FTO rs9939609,与中国人口中GDM风险增加显著相关,特别是在30岁及以上的女性中.
- 这些发现表明,某些遗传变异可能在老年母亲的GDM发育中发挥更为关键的作用.
- 已识别的SNP可以作为敏感人群中GDM风险分层的潜在生物标志物.
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