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Updated: Jun 5, 2025

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维生素D和与毒症儿童维生素D代谢相关的分子
Caizhi Huang1, Cong Zhang1, Jie Zhang1
1Department of Laboratory Medicine, Hunan Children's Hospital, Changsha, Hunan Province, 410007, People's Republic of China.
Journal of inflammation research
|December 11, 2024
概括
患有败血症的儿童经常有低维生素D水平. 维生素D缺乏与更长时间的重症监护室 (ICU) 停留有关,这突显了维生素D在儿科败血症管理中的重要性.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 败血症是儿童的一种危及生命的疾病,通常与复杂的代谢障碍有关.
- 维生素D在免疫功能中起着至关重要的作用,并具有潜在的免疫调节作用.
- 儿童群体中维生素D代谢和败血症结果之间的相互作用需要进一步阐明.
研究的目的:
- 在被诊断患有败血症的儿童中调查维生素D水平和相关代谢分子之间的关联.
- 为了确定患有败血症的住院儿童中低维生素D的患病率.
- 探索维生素D状态,败血症严重程度和临床结果之间的关系,包括死亡率和重症监护室 (ICU) 的入院.
主要方法:
- 研究了一组98名患有败血症的住院儿童.
- 血液样本被分析为维生素D,维生素D结合蛋白 (VDBP),酶 (DHCR7,CYP2R1,CYP24A1),cathelicidin (CATH) 和炎症标志物 (IL-6,PCT,CRP,WBC).
- 进行了统计分析,以评估与败血症严重程度和结果的相关性和独立关联.
主要成果:
- 几乎一半 (46.94%) 的败血症儿童呈现出维生素D下降症.
- 患有维生素D低水平的儿童表现出维生素D代谢分子水平的改变 (较低的CYP2R1,CATH;较高的CYP24A1) 和炎症标志物 (PCT,IL-6) 的增加.
- 低维他命症D独立地与急症监护室住院的需要有关,但与严重的败血症或死亡率无关.
结论:
- 患有败血症的儿童表现出维生素D缺乏的高患病率.
- 参与维生素D代谢的特定分子 (VDBP,CYP2R1,CYP24A1) 参与了在败血症期间调节维生素D水平.
- 低维他命症D是儿科败血症患者ICU入院的独立预测因素,强调需要监测和潜在的补充.
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