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Updated: Jun 5, 2025

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
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来自核中的线粒体编码蛋白质ATP8的外源表达in vivo

David V Begelman1,2, Bhavna Dixit1, Carly Truong1

  • 1SENS Research Foundation, Mountain View, CA 94041, USA.

Molecular therapy. Methods & clinical development
|December 11, 2024
PubMed
概括

线粒体DNA (mtDNA) 突变可以使用全位表达来修复,其中核表达的基因恢复线粒体功能. 这项研究成功地证明了小鼠ATP8基因的全位表达,为线粒体疾病提供了潜在的基因疗法.

关键词:
在ATP8基因.形表达的表达方式是全形表达.在活体中,基因疗法.线粒体DNA突变的突变我们的mtDNA mtDNA安全港口表达方式转基因小鼠的转基因小鼠

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