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Updated: Jun 5, 2025

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在聚乙烯抗生素生物合成中意外的酶催化 [4+2] 循环添加和重新排列

Rory Little1, Fernanda C R Paiva2, Rob Jenkins3

  • 1Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, United Kingdom.

Nature catalysis
|December 11, 2024
PubMed
概括

研究人员发现了新的酶,Tsn11和Tsn15,参与了四素抗生素生物合成. Tsn11执行一个类似于Diels-Alder的反应,而Tsn15重新排列中间体以形成最终的抗生素结构.

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