与黑色素瘤相关的ncRNA的知识图和前沿趋势:从2006年到2023年的文献分析分析
Ru Wang1, Xiao-Yan Zhu2, Yi Wang3,4
1Department of Pediatrics, Xinzhou District People's Hospital, Wuhan, Hubei, China.
Frontiers in oncology
|December 11, 2024
概括
本文献分析揭示了恶性黑色素瘤 (MM) 中非编码RNA (ncRNA) 的日益增长的研究领域. 它强调了这个快速发展的领域的关键趋势,合作和未来方向.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 恶性黑色素瘤 (MM) 是一种重要的皮肤癌.
- 在MM中对非编码RNA (ncRNA) 的研究正在迅速扩大.
- 图书统计分析对于理解研究趋势和合作至关重要.
研究的目的:
- 对MM的ncRNA研究进行全面的文献分析.
- 总结知识图表并确定前沿趋势.
- 为该领域的研究人员提供新的视角和合作方向.
主要方法:
- 从科学网络 (2006-2023) 出版物的图书统计分析.
- 使用R Studio,Scimago Graphica,VOSviewer和Citespace进行数据分析.
- 分析出版物,国家,期刊,机构,作者,关键词和参考文献,以构建网络图形.
主要成果:
- 发表了1222篇文章,年增长率为25.02%.
- 中国在出版物方面处于领先地位,上海通大学是最具生产力的机构.
- 关键的研究领域包括长非编码RNA,免疫疗法和外体,其中"功能作用"和"人类癌症"是新兴热点.
结论:
- 在黑色素瘤的生物行为 (扩散,入侵,转移,药物耐药性) 中,ncRNAs起着至关重要的作用.
- ncRNAs具有早期诊断,向治疗和黑色素瘤疗效评估的巨大潜力.
- 这项研究提供了对黑色素瘤ncRNA研究的知识图,趋势和潜在研究合作的见解.
相关概念视频
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K


