对基因编辑和肌痛性侧面硬化症 (从2004年到2024年) 的文献分析分析
Hejia Wan1,2, Wenli Qian1,3, Bingqi Wei1,4
1School of Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Frontiers in neuroscience
|December 11, 2024
概括
对肌缩侧面硬化症 (ALS) 的基因编辑研究显示出稳定的趋势,重点关注免疫和炎症机制. 像RNA编辑这样的新兴领域提供了新的治疗途径.
科学领域:
- 基因编辑用于肌缩侧面硬化症 (ALS) 的图书统计分析.
背景情况:
- 基因编辑技术正在探索潜在的ALS治疗方法.
- 了解研究环境对于推进治疗策略至关重要.
研究的目的:
- 全面审查ALS的基因编辑研究.
- 确定ALS基因编辑的当前趋势和未来方向.
主要方法:
- 在Web of Science,PubMed和Scopus上进行系统的文献搜索.
- 使用R,CiteSpace和VOSviewer进行文献计量分析.
- 空间时间分布,作者,主题和关键词的分析.
主要成果:
- 对于ALS的基因编辑领域在过去十年中稳定了下来.
- 目前的研究重点是炎症和免疫机制,相关疾病和细胞因子.
- 确定了潜在的研究合作者和关键主题领域.
结论:
- RNA编辑,反意义寡核酸和甘氨酸受体是最先进的主题.
- 该领域正在迅速发展,为ALS的科学研究和临床应用提供了新的想法.
相关概念视频
RNA Editing
8.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
8.9K
Animal Mitochondrial Genetics
7.5K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.5K


