循环RNA介导的心血管疾病的调节
Ke-Yun Cheng1, Si-Wei Wang1, Tian Lan1
1Panvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.
Frontiers in cardiovascular medicine
|December 11, 2024
概括
循环RNAs (circRNAs) 是心血管疾病 (CVD) 的关键调节者,是全球死亡的主要原因. 研究强调了它们的多样性作用,为心脏和血管疾病提供了潜在的新治疗点.
科学领域:
- 生物化学 生化学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 心血管疾病 (CVD) 是全球主要的健康负担,在全球造成大量死亡.
- 非编码RNA转录,特别是循环RNA (circRNAs),已经成为各种生物过程中的关键调节者,包括心血管功能.
- 近期深度测序技术的进步促进了许多参与心血管疾病的circRNAs的识别和表征.
研究的目的:
- 为循环RNAs (circRNAs) 及其在心血管疾病 (CVDs) 中的多方面的作用提供全面的概述.
- 检查血管系统内circRNAs的调节功能及其对心血管健康和疾病的影响.
- 突出circRNAs作为心血管疾病管理和治疗的治疗点的潜力.
主要方法:
- 对调查心血管疾病中circRNAs的研究进行文献综述.
- 分析深度测序数据以识别和表征相关的circRNAs.
- 综合目前关于circRNAs血管保护和有害功能的研究.
主要成果:
- 越来越多的证据表明,circRNAs在心血管疾病的发展和进展中发挥着重要的调节作用.
- 已经确定了具有明显的血管保护或有害功能的特定circRNAs,影响诸如炎症,血管生成和心脏重塑等过程.
- 循环RNAs的多样性功能为心血管医学中新的治疗策略提供了有希望的途径.
结论:
- 循环RNA是心血管调节的组成部分,对疾病发病有深远的影响.
- 了解不同circRNA在心血管疾病中的特定作用对于开发有针对性的治疗干预至关重要.
- 心血管医学中的circRNA研究领域正在迅速扩大,为治疗心脏和血管疾病的创新治疗提供了希望.
相关概念视频
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Regulation of the Cardiovascular System
424
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
424
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
57
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
57
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Cardiovascular Drugs: Classification based on Therapeutic Indications
2.0K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.0K
Pathophysiology of Cardiac Performance
557
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
557


