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目前和新兴的工具用于同时评估移植中感染和排斥风险
Dhakshayini Tharmaraj1,2, William R Mulley1,2, Claire Dendle2,3
1Department of Nephrology, Monash Health, Clayton, VIC, Australia.
Frontiers in immunology
|December 11, 2024
概括
在移植受体中平衡感染和排斥风险是具有挑战性的. 新兴的生物标志物,如来自捐赠者的无细胞DNA和尿液化学因子,为准确的风险预测提供了希望,改善了患者的治疗结果.
科学领域:
- 移植医学 移植医学
- 免疫学 免疫学 免疫学
- 发现生物标志物的发现.
背景情况:
- 感染和排斥显著影响移植寿命和存活率.
- 目前评估感染和排斥风险的方法不准确.
- 感染和排斥之间的复杂相互作用使临床决策复杂化.
研究的目的:
- 为了应对在移植受体中平衡感染和排斥风险的挑战.
- 探索改进的方法来预测感染和排斥.
- 通过更好的风险分层来优化移植接受者护理和结果.
主要方法:
- 对目前的免疫和非免疫标记进行风险评估的审查.
- 评估新兴生物标志物,如来自供体的无细胞DNA和尿路化学因子 (CXCL9,CXCL10).
- 整合传统和新型风险评估工具.
主要成果:
- 来自捐赠者的无细胞DNA和尿液化学因子显示出预测排斥的前景.
- 这些生物标志物可能会减少侵入性全移植活检的需要.
- 综合风险评估可以分层并行感染和排斥风险.
结论:
- 优化移植结果需要了解动态免疫状态和并行风险.
- 最少侵入性的生物标志物可以帮助风险分层和监测.
- 基于风险评估的个性化免疫抑制管理可以改善全移植和患者的存活率.
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