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传统中医及其成分有效降低免疫检查点抑制剂介导的抗性

Mingxin Guo¹, Wentong Fang², Zhiqiang Hu¹

¹Department of Pharmacy, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China.

Frontiers in immunology

|December 11, 2024

概括

免疫检查点抑制剂 (ICI) 在癌症治疗中表现有前途,但面临抗药性. 传统中医 (TCM) 可能有助于克服这种抵抗,提高免疫疗法的疗效,并减少副作用.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

免疫疗法,特别是免疫检查点抑制剂 (ICI),是癌症治疗的关键策略.
显著的挑战包括在各种癌症中对ICI产生耐药性的发展.
传统中医 (TCM) 提供一种具有低毒性的补充方法.

研究的目的:

审查对免疫检查点抑制剂 (ICI) 耐药性的机制.
探索传统中医药 (TCM) 在克服ICI耐药性的潜力.
评估TCM在提高免疫疗法疗效和降低毒性方面的作用.

主要方法:

关于ICI耐药性的最新研究的文献综述.
对研究TCM与现代癌症疗法结合的研究进行分析.
对TCM对免疫反应和瘤微环境的影响的综合发现.

主要成果:

确定了促进ICI耐药性在肺癌,结肠癌和黑色素瘤等癌症中的关键机制.
突出了几种TCM配方和化合物,有可能调节对瘤的免疫反应.
观察到的证据表明TCM可以提高ICI的有效性并减轻不良影响.

结论:

ICI耐药性是癌症免疫治疗中的一个主要障碍.
传统医学提出了一个有希望的策略,通过解决耐药性机制来增强ICI治疗.
将TCM与ICI结合起来可以改善患者的治疗结果和治疗耐受性.

关键词:

中国草药,中国草药.药物耐药性耐药性药物耐药性免疫检查点抑制剂免疫检查点抑制剂传统的中国医药传统的中国医药.瘤免疫疗法免疫疗法

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