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重编程瘤微环境 - 巨细胞成为乳腺癌免疫治疗中的关键参与者
1Department of Medicine and Dentistry, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
Frontiers in immunology
|December 11, 2024
概括
乳腺癌发病率正在上升,原因是治疗耐药性. 瘤微环境中的瘤相关巨细胞 (TAM) 促进免疫逃避,为改善乳腺癌存活率提供新的治疗点.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 乳腺癌是全球最常见的癌症,预计到2040年发病率和死亡率将增加.
- 治疗耐药性和癌细胞复发与瘤进化和免疫抑制瘤微环境 (TME) 有关.
研究的目的:
- 本综述侧重于乳腺癌TME中瘤相关巨细胞 (TAM) 在免疫治疗中的作用.
- 探索TAMs作为影响免疫逃避和乳腺癌治疗结果的关键细胞组件.
主要方法:
- 关于乳腺癌中瘤相关巨细胞的当前文献的综述.
- 在TME内分析巨细胞可塑性和表型转化 (M1到M2).
- 在乳腺癌中检查TAM介导的免疫逃避机制.
主要成果:
- TAMs,特别是那些具有前瘤M2表型的TAMs,对于促进乳腺癌中的免疫逃避至关重要.
- 癌细胞操纵TME以促进TAMs的M2极化,阻碍抗瘤免疫力.
- 了解TAM的作用是开发新型乳腺癌免疫疗法的关键.
结论:
- 向TAM是克服治疗耐药性和改善乳腺癌患者长期生存的有希望的策略.
- 未来的治疗方法可能涉及工程巨细胞,M2特异性药物或新的巨细胞介导药物递送系统.
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