癌症免疫治疗中的淋巴细胞激活基因3:功能,预后生物标志物和治疗潜力
Ke Ren1, Hayam Hamdy2, Abdo Meyiah1
1Department of Biosciences and Bioinformatics, School of Science, Suzhou Municipal Key Lab in Biomedical Sciences and Translational Immunology, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.
Frontiers in immunology
|December 11, 2024
概括
淋巴细胞激活基因3 (LAG-3) 是一个关键的免疫检查点,可以抑制抗瘤免疫力. 用抗体或CAR T细胞等疗法向LAG-3显示出增强癌症治疗和改善患者治疗结果的希望.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 淋巴细胞激活基因3 (LAG-3) 是T细胞表达的关键免疫检查点受体.
- LAG-3信号抑制T细胞激活,导致瘤微环境中的免疫逃避.
- 对LAG-3的失调通过抑制抗瘤免疫反应促进瘤的进展.
研究的目的:
- 审查LAG-3在癌症中的免疫抑制中的多方面的作用.
- 探索LAG-3及其连接体之间的相互作用.
- 评估LAG-3作为瘤学中的预后生物标志物和治疗点.
主要方法:
- 关于LAG-3的临床前和临床研究的文献综述.
- 分析LAG-3在免疫抑制和抗瘤免疫中的功能.
- 检查针对LAG-3的治疗策略,包括抗体,小分子和CAR T细胞.
主要成果:
- 在T细胞上的LAG-3表达与抑制的抗瘤免疫力和瘤进展相关.
- LAG-3 作为各种癌症的潜在预后生物标志物.
- 针对LAG-3的治疗药物显示出增强抗瘤反应的潜力.
结论:
- 在癌症中,LAG-3是免疫抑制的重要调节者.
- 针对LAG-3提供了一个有希望的策略,以重振抗瘤免疫力.
- 进一步的研究对于优化基于LAG-3的疗法来改善患者的治疗结果至关重要.
相关概念视频
Tumor Immunotherapy
476
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
476
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K


