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TriHex 2.0-推进皮肤健康科学和TriHex技术

Alan D Widgerow¹, Mary E Ziegler², Faiza Shafiq²

¹Division Chief Research, Professor Plastic Surgery Center for Tissue Engineering, University of California, Irvine, California, USA.

Journal of cosmetic dermatology

|December 11, 2024

概括

添加了Octapeptide-45的TriHex 2.0,通过显著提高弹性素和氨酸水平,增强了细胞外矩阵重塑和伤口愈合. 这种先进的组合与原来的TriHex技术相比,提供了优越的皮肤益处.

科学领域:

皮肤病学和化品科学
生物化学生物化学
分子生物学分子生物学

背景情况:

原来的TriHex技术是Tripeptide-1和Hexapeptide-12的组合,通过清除降解的原蛋白和弹性质碎片并刺激新的合成来调节细胞外基质 (ECM).
将Octapeptide-45 (Octa) 纳入TriHex技术 (形成TriHex 2.0) 旨在增强氨酸 (HA) 生产并改善伤口愈合.
这项研究研究了Octa与TriHex技术的协同效应.

研究的目的:

通过实体模型验证Octapeptide-45 (Octa) 与TriHex技术的协同作用.
评估TriHex 2.0对细胞外矩阵组件的影响,包括弹性素,氨酸和底层膜.
分析由TriHex 2.0.0.引发的基因和蛋白质表达变化.

主要方法:

使用ECM组件 (elastin,HA,底层膜) 的组织学评估进行ex vivo验证.
通过批量和单细胞测序进行基因表达分析,以确定分子变化.
使用组织学染色方法对差异表达基因的蛋白质表达分析.

主要成果:

奥克塔与TriHex协同作用,显著上调参与ECM和底层膜调节的基因 (p <0.05).
组织学分析显示,用TriHex (43%) 和TriHex 2.0 (42%) (p <0.05) 显著增加了托波拉斯.
氨酸水平增加了69%的TriHex (p < 0.01) 和160%的TriHex 2.0 (p < 0.001) 的时间.
单细胞测序显示,TriHex 2.0还促进了底层膜生理学,干细胞招募和纤维细胞对衰老的保护.

结论:

TriHex 2.0 代表了 TriHex 技术的显著进步,提供了增强的 ECM 重塑和伤口愈合.
TriHex 2.0的主要好处包括增加弹性质和HA刺激,改善底层膜功能,增强质细胞的伤口愈合,以及对纤维细胞的抗衰老作用.
TriHex 2.0对于皮肤预调和术后护理有好处,准DEJ强化,衰老细胞,并促进ECM重塑和伤口愈合.

关键词:

弹性弹性纤维是一种弹性.细胞外矩阵是细胞外矩阵.氨酸是什么? 氨酸是什么?酸是一种酸.局部代理人局部代理人局部抗衰老药物局部抗衰老药物

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