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Updated: Jun 5, 2025

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
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Published on: December 2, 2022

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在TDP1拼接部位的突变导致HAP1细胞对拓酶I抑制的过敏

Chen Gang Goh1, Aldo S Bader1, Tuan-Anh Tran1

  • 1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, UK.

Nucleic acids research
|December 11, 2024
PubMed
概括

由于TDP1 (tyrosyl-DNA phosphodiesterase1) 缺乏,HAP1细胞对坎普托素呈现过敏. 这种缺陷源于导致TDP1功能丧失的拼接部位突变,影响了DNA修复研究.

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