在患有神经性厌食症的女性青少年中,高级大脑衰老的过渡性模式
Tatiana Stratton1, Klaas Bahnsen2, Daniel Geisler2
1Department of Psychology, University of Bath, Bath, UK.
The British journal of psychiatry : the journal of mental science
|December 11, 2024
概括
神经性厌食症的营养不良会加速大脑的衰老,特别是灰质. 重量恢复显著扭转了这种先进的大脑年龄,这表明它是短暂的,并与营养状况有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 神经性厌食症是一种精神疾病,其特点是营养不良和体重低.
- 先进的大脑衰老,指的是大脑形态学中与年龄相关的加速变化,与精神病理学和不良结果有关.
研究的目的:
- 调查急性神经性厌食症和康复期间大脑晚年化的横截面和纵向模式.
- 确定大脑年龄,营养状况和临床结果之间的关系.
主要方法:
- 用T1权重的MRI扫描来评估基于灰色和白色物质的脑年龄,对129名急性体重不足患者,39名康复患者和167名健康对照 (12-23岁) 进行了评估.
- 大脑预测年龄差异 (BrainAGE) 是通过从大脑年龄 (BrainAGE_GM和BrainAGE_WM) 中减去时间年龄来计算的.
- 大约3个月的营养治疗后,95名患者被重新评估.
主要成果:
- 与对照组相比,急性体重不足患者的灰色物质BrainAGE (BrainAGE_GM) 显著增加,而白色物质BrainAGE (BrainAGE_WM) 的差异较小.
- 在部分重量恢复后,BrainAGE_GM显著下降.
- 更大的体重增加与纵向样本中BrainAGE_GM的更大正常化相关.
结论:
- 神经性厌食症的营养不良是高级灰质大脑年龄的关键预测因素.
- 这种先进的大脑衰老似乎是短暂的,在营养康复和体重恢复后在很大程度上得到解决.
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